The Environmental Influences on Child Health Outcomes (ECHO) Program will evaluate environmental factors affecting children's health (perinatal, neurodevelopmental, obesity, respiratory, and positive health outcomes) by pooling cohorts composed of >50,000 children in the largest US study of its kind. Our objective was to identify opportunities for studying chemicals and child health using existing or future ECHO chemical exposure data. We described chemical-related information collected by ECHO cohorts and reviewed ECHO-relevant literature on exposure routes, sources, and environmental and human monitoring. Fifty-six ECHO cohorts have existing or planned chemical biomonitoring data for mothers or children. Environmental phenols/parabens, phthalates, metals/metalloids, and tobacco biomarkers are each being measured by ≥15 cohorts, predominantly during pregnancy and childhood, indicating ample opportunities to study child health outcomes. Cohorts are collecting questionnaire data on multiple exposure sources and conducting environmental monitoring including air, dust, and water sample collection that could be used for exposure assessment studies. To supplement existing chemical data, we recommend biomonitoring of emerging chemicals, nontargeted analysis to identify novel chemicals, and expanded measurement of chemicals in alternative biological matrices and dust samples. ECHO's rich data and samples represent an unprecedented opportunity to accelerate environmental chemical research to improve the health of US children.
Keywords: Chemicals; Children’s health; Environmental exposures; Environmental influences on child health outcomes.
Conflict of interest statement
Understanding childhood obesity in the US: the NIH environmental influences on child health outcomes (ECHO) program.Int J Obes (Lond). 2020 Mar;44(3):617-627. doi: 10.1038/s41366-019-0470-5. Epub 2019 Oct 24. Int J Obes (Lond). 2020. PMID: 31649277
A review of maternal prenatal exposures to environmental chemicals and psychosocial stressors-implications for research on perinatal outcomes in the ECHO program.J Perinatol. 2020 Jan;40(1):10-24. doi: 10.1038/s41372-019-0510-y. Epub 2019 Oct 15. J Perinatol. 2020. PMID: 31616048 Free PMC article. Review.
Identifying and Prioritizing Chemicals with Uncertain Burden of Exposure: Opportunities for Biomonitoring and Health-Related Research.Environ Health Perspect. 2019 Dec;127(12):126001. doi: 10.1289/EHP5133. Epub 2019 Dec 18. Environ Health Perspect. 2019. PMID: 31850800 Free PMC article.
Co-exposure to non-persistent organic chemicals among American pre-school aged children: A pilot study.Int J Hyg Environ Health. 2017 Mar;220(2 Pt A):55-63. doi: 10.1016/j.ijheh.2016.10.008. Epub 2016 Oct 21. Int J Hyg Environ Health. 2017. PMID: 27789189 Free PMC article.
The child health exposure analysis resource as a vehicle to measure environment in the environmental influences on child health outcomes program.Curr Opin Pediatr. 2018 Apr;30(2):285-291. doi: 10.1097/MOP.0000000000000601. Curr Opin Pediatr. 2018. PMID: 29406438 Free PMC article. Review.
- American College of Obstetricians and Gynecologists Committee on Health Care for Underserved Women, American Society for Reproductive Medicine Practice Committee, The University of California San Francisco Program on Reproductive Health and the Environment Exposure to toxic environmental agents. No. 575. The American College of Obstetricians and Gynecologists: Washington, D.C., 2013.
- President’s Cancer Panel. Reducing Environmental Cancer Risk: What We Can Do Now. U.S. Department of Health and Human Services; Bethesda, MD, 2010.
- American Academy of Pediatrics. Pediatric Environmental Health. American Academy of Pediatrics Council on Environmental Health: Itasca, IL, 2018.
- ACOG Committee Opinion No. 575. Exposure to toxic environmental agents. Obstet Gynecol 2013; 122: 931–935. - PubMed
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