Autologous platelet-rich plasma (PRP) is a biological preparation made from the patient's own plasma that contains a platelet concentration above the whole blood baseline. Owing to the release of growth factors and other cytokines after degranulation, platelets have a central role in inflammation and in different stages of the healing process. For this reason, PRP-derived products have been used to enhance healing of musculoskeletal injuries and modulate progression of inflammatory processes, including osteoarthritis (OA). Osteoarthritis is one of the main causes of musculoskeletal disabilities in horses, and currently, there is no effective treatment for this disease. Treatments that focus on the modulation of inflammation and disease progression offer new hope for OA. Platelet-rich plasma provides a more practical and accessible option of therapy compared to other forms of biological treatment (i.e., stem cell therapies) and is believed to induce the production of functional matrix. However, several factors related to PRP production, including methods of preparation and application, and intraindividual variability, lead to an inconsistent product, precluding reliable conclusions about its efficacy for clinical use. The aim of this study was to review the benefits related to the clinical use of PRP in OA as well as factors that influence its use, the limitations of this treatment, and future directions of PRP research and therapy.
Keywords: Growth factors; Horse; Osteoarthritis; Platelet-rich plasma.
Copyright © 2019 The Author(s). Published by Elsevier Inc. All rights reserved.
Platelet-rich therapies for musculoskeletal soft tissue injuries.Cochrane Database Syst Rev. 2014 Apr 29;2014(4):CD010071. doi: 10.1002/14651858.CD010071.pub3. Cochrane Database Syst Rev. 2014. PMID: 24782334 Free PMC article. Review.
Platelet-rich therapies for musculoskeletal soft tissue injuries.Cochrane Database Syst Rev. 2013 Dec 23;(12):CD010071. doi: 10.1002/14651858.CD010071.pub2. Cochrane Database Syst Rev. 2013. PMID: 24363098 Updated. Review.
The anti-inflammatory and matrix restorative mechanisms of platelet-rich plasma in osteoarthritis.Am J Sports Med. 2014 Jan;42(1):35-41. doi: 10.1177/0363546513507766. Epub 2013 Nov 5. Am J Sports Med. 2014. PMID: 24192391
The influence of environmental variables on platelet concentration in horse platelet-rich plasma.Acta Vet Scand. 2016 Jul 4;58(1):45. doi: 10.1186/s13028-016-0226-3. Acta Vet Scand. 2016. PMID: 27377748 Free PMC article.
Anti-Inflammatory Effects of Novel Standardized Platelet Rich Plasma Releasates on Knee Osteoarthritic Chondrocytes and Cartilage in vitro.Curr Pharm Biotechnol. 2019;20(11):920-933. doi: 10.2174/1389201020666190619111118. Curr Pharm Biotechnol. 2019. PMID: 31237204