Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia

J Thromb Haemost. 2020 Apr;18(4):844-847. doi: 10.1111/jth.14768. Epub 2020 Mar 13.


Background: In the recent outbreak of novel coronavirus infection in Wuhan, China, significantly abnormal coagulation parameters in severe novel coronavirus pneumonia (NCP) cases were a concern.

Objectives: To describe the coagulation feature of patients with NCP.

Methods: Conventional coagulation results and outcomes of 183 consecutive patients with confirmed NCP in Tongji hospital were retrospectively analyzed.

Results: The overall mortality was 11.5%, the non-survivors revealed significantly higher D-dimer and fibrin degradation product (FDP) levels, longer prothrombin time and activated partial thromboplastin time compared to survivors on admission (P < .05); 71.4% of non-survivors and 0.6% survivors met the criteria of disseminated intravascular coagulation during their hospital stay.

Conclusions: The present study shows that abnormal coagulation results, especially markedly elevated D-dimer and FDP are common in deaths with NCP.

Keywords: D-dimer; coagulation parameter; disseminated intravascular coagulation; fibrin degradation product; novel coronavirus pneumonia.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Betacoronavirus*
  • Blood Coagulation*
  • COVID-19
  • China
  • Coronavirus Infections / mortality*
  • Coronavirus Infections / physiopathology*
  • Disseminated Intravascular Coagulation / mortality*
  • Disseminated Intravascular Coagulation / virology*
  • Female
  • Fibrin Fibrinogen Degradation Products / analysis
  • Humans
  • Male
  • Middle Aged
  • Pandemics
  • Partial Thromboplastin Time
  • Pneumonia, Viral / mortality*
  • Pneumonia, Viral / physiopathology*
  • Prothrombin Time
  • Retrospective Studies
  • SARS-CoV-2
  • Young Adult


  • Fibrin Fibrinogen Degradation Products
  • fibrin fragment D