Beware of the Uric Acid: Severe Azathioprine Myelosuppression in a Patient With Juvenile Idiopathic Arthritis and Hereditary Xanthinuria

MeSH terms

• Aldehyde Oxidase / deficiency*
• Aldehyde Oxidase / genetics
• Antirheumatic Agents / administration & dosage
• Antirheumatic Agents / adverse effects
• Antirheumatic Agents / pharmacokinetics
• Arthritis, Juvenile / drug therapy*
• Arthritis, Juvenile / immunology
• Azathioprine* / administration & dosage
• Azathioprine* / adverse effects
• Azathioprine* / pharmacokinetics
• Bone Marrow Failure Disorders* / blood
• Bone Marrow Failure Disorders* / chemically induced
• Bone Marrow Failure Disorders* / therapy
• Erythrocyte Transfusion / methods
• Humans
• IgA Deficiency / diagnosis*
• Immune Tolerance / genetics
• Immunologic Tests / methods
• Male
• Pharmacogenomic Testing / methods
• Purine-Pyrimidine Metabolism, Inborn Errors* / diagnosis
• Purine-Pyrimidine Metabolism, Inborn Errors* / genetics
• Purine-Pyrimidine Metabolism, Inborn Errors* / physiopathology
• Sulfurtransferases / genetics
• Uric Acid* / blood
• Uric Acid* / urine
• Xanthine
• Xanthine Dehydrogenase / deficiency*
• Xanthine Dehydrogenase / genetics
• Young Adult