P-TEFb as A Promising Therapeutic Target

Molecules. 2020 Feb 14;25(4):838. doi: 10.3390/molecules25040838.


The positive transcription elongation factor b (P-TEFb) was first identified as a general factor that stimulates transcription elongation by RNA polymerase II (RNAPII), but soon afterwards it turned out to be an essential cellular co-factor of human immunodeficiency virus (HIV) transcription mediated by viral Tat proteins. Studies on the mechanisms of Tat-dependent HIV transcription have led to radical advances in our knowledge regarding the mechanism of eukaryotic transcription, including the discoveries that P-TEFb-mediated elongation control of cellular transcription is a main regulatory step of gene expression in eukaryotes, and deregulation of P-TEFb activity plays critical roles in many human diseases and conditions in addition to HIV/AIDS. P-TEFb is now recognized as an attractive and promising therapeutic target for inflammation/autoimmune diseases, cardiac hypertrophy, cancer, infectious diseases, etc. In this review article, I will summarize our knowledge about basic P-TEFb functions, the regulatory mechanism of P-TEFb-dependent transcription, P-TEFb's involvement in biological processes and diseases, and current approaches to manipulating P-TEFb functions for the treatment of these diseases.

Keywords: HIV; P-TEFb; RNA polymerase II; autoimmune diseases; cancer; cardiac hypertrophy; infectious diseases; inflammation; inhibitors; transcription elongation.

Publication types

  • Review

MeSH terms

  • Gene Expression Regulation, Viral / drug effects
  • HIV Infections / drug therapy
  • HIV Infections / genetics*
  • HIV Infections / virology
  • HIV-1 / genetics
  • HIV-1 / pathogenicity
  • Humans
  • Positive Transcriptional Elongation Factor B / antagonists & inhibitors
  • Positive Transcriptional Elongation Factor B / genetics*
  • Transcription, Genetic / drug effects*
  • tat Gene Products, Human Immunodeficiency Virus / genetics*


  • tat Gene Products, Human Immunodeficiency Virus
  • Positive Transcriptional Elongation Factor B