Pathophysiology of chronic peripheral ischemia: new perspectives

Salvatore Santo Signorelli; Luca Vanella; Nader G Abraham; Salvatore Scuto; Elisa Marino; Petra Rocic

doi:10.1177/2040622319894466

Pathophysiology of chronic peripheral ischemia: new perspectives

Ther Adv Chronic Dis. 2020 Feb 5:11:2040622319894466. doi: 10.1177/2040622319894466. eCollection 2020.

Authors

Salvatore Santo Signorelli¹, Luca Vanella², Nader G Abraham³, Salvatore Scuto⁴, Elisa Marino⁴, Petra Rocic³

Affiliations

¹ Department of Clinical and Experimental Medicine, University of Catania, University Hospital 'G. Rodolico', Catania, 95124, Italy.
² Department of Drug Science, University of Catania, Catania, Italy.
³ Departments of Medicine, Pharmacology and Gastroenterology, New York Medical College, Valhalla, NY, USA.
⁴ Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy.

Abstract

Peripheral arterial disease (PAD) affects individuals particularly over 65 years old in the more advanced countries. Hemodynamic, inflammatory, and oxidative mechanisms interact in the pathophysiological scenario of this chronic arterial disease. We discuss the hemodynamic, muscle tissue, and oxidative stress (OxS) conditions related to chronic ischemia of the peripheral arteries. This review summarizes the results of evaluating both metabolic and oxidative markers, and also therapy to counteract OxS. In conclusion, we believe different pathways should be highlighted to discover new drugs to treat patients suffering from PAD.

Keywords: biomarkers; inflammation; pathophysiology; peripheral arterial disease; therapy.

Publication types

Review