Solvent-free synthesis of isoindolo[2,1-c]pyrazolo[1,5-a]quinazoline and pyrazolo[5',1':2,3]pyrimido[6,1-a]isoindol derivatives through a one-pot three-component reaction

Meysam Alizadeh-Kouzehrash; Abbas Rahmati

doi:10.1007/s11030-020-10052-y

Solvent-free synthesis of isoindolo[2,1-c]pyrazolo[1,5-a]quinazoline and pyrazolo[5',1':2,3]pyrimido[6,1-a]isoindol derivatives through a one-pot three-component reaction

Mol Divers. 2021 May;25(2):1123-1130. doi: 10.1007/s11030-020-10052-y. Epub 2020 Feb 19.

Authors

Meysam Alizadeh-Kouzehrash¹, Abbas Rahmati²

Affiliations

¹ Department of Chemistry, University of Isfahan, P. O. Box 81746-73441, Isfahan, Iran.
² Department of Chemistry, University of Isfahan, P. O. Box 81746-73441, Isfahan, Iran. a.rahmati@sci.ui.ac.ir.

PMID: 32076910
DOI: 10.1007/s11030-020-10052-y

Abstract

Some 5-substituted 3-aminopyrazoles were used for the synthesis of isoindolo[2,1-c]pyrazolo[1,5-a]quinazoline and pyrazolo[5',1':2,3]pyrimido[6,1-a]isoindol derivatives via a mild and efficient one-pot three-component reaction with 2-formylbenzoic acid and different CH-acids under solvent-free condition.

Keywords: Heterocyclic compounds; Isoindoline; Multicomponent reactions; Pyrazole.

MeSH terms

Catalysis
Green Chemistry Technology
Isoindoles / chemical synthesis*
Pyrazoles / chemical synthesis*
Pyrazoles / chemistry
Quinazolines / chemical synthesis*

Substances

Isoindoles
Pyrazoles
Quinazolines