Not Fade Away: Mechanisms of Neuronal ATP Homeostasis

Neuron. 2020 Feb 19;105(4):591-593. doi: 10.1016/j.neuron.2020.01.024.


In this issue of Neuron, Ashrafi et al. (2020) identify a feedforward signaling mechanism that couples neuronal activity to the homeostatic maintenance of axonal and synaptic ATP production. This mechanism is achieved via changes in cytoplasmic calcium and activation of brain-specific, mitochondrial MICU3.

Publication types

  • Comment

MeSH terms

  • Adenosine Triphosphate
  • Calcium*
  • Homeostasis
  • Neurons
  • Synaptic Transmission*


  • Adenosine Triphosphate
  • Calcium