Advanced Glycation End Product Accumulation is Associated with Lower Cognitive Performance in an Older General Population: The Nagahama Study

J Alzheimers Dis. 2020;74(3):741-746. doi: 10.3233/JAD-190878.

Abstract

Accumulation of advanced glycation end products (AGEs) has been linked with cognitive decline as a risk factor based on the analysis in small populations. We investigated the association between skin autofluorescence of AGEs and global cognitive function in a Japanese older (≥60 years) population (n = 4,041). The AGEs quartiles were inversely associated with the Revised Hasegawa's Dementia Scale score (Q1: reference, Q2: β= -0.011, p = 0.537, Q3: β= -0.043, p = 0.016, Q4: β= -0.064, p < 0.001) independent of major risk factors. Accumulation of AGEs was associated with lower cognitive performance in older adults.

Keywords: Advanced glycation end products; cognitive function; epidemiological studies; population at risk.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Cognition Disorders / epidemiology
  • Cognition Disorders / metabolism
  • Cognition Disorders / psychology
  • Cognition*
  • Cross-Sectional Studies
  • Educational Status
  • Female
  • Fingers / anatomy & histology
  • Fluorescence
  • Glycation End Products, Advanced / metabolism*
  • Humans
  • Japan / epidemiology
  • Male
  • Middle Aged
  • Neuropsychological Tests
  • Psychomotor Performance*
  • Risk Factors
  • Skin

Substances

  • Glycation End Products, Advanced