Amla Therapy as a Potential Modulator of Alzheimer's Disease Risk Factors and Physiological Change

J Alzheimers Dis. 2020;74(3):713-733. doi: 10.3233/JAD-191033.

Abstract

There is currently no effective treatment for Alzheimer's disease (AD), the most common form of dementia. It has been proposed, however, that a modest delay in onset can significantly reduce the number of cases. Thus, prevention and intervention strategies are currently the focus of much research. In the search for compounds that potentially confer benefit, the Amla fruit and its extracts have drawn attention. Amla preparations have been used for centuries in traditional Indian medicine systems such as Ayurveda, with various parts of the plant used to treat a variety of diseases. Here we review many animal-based studies, and some clinical trials, which have shown that Amla, and its extracts, exert many positive effects on dyslipidemia, hyperglycemia, inflammation, oxidative stress, apoptosis, and autophagy, that contribute to AD risk. Collectively, this evidence suggests that Amla may be of value as part of an effective disease-delaying treatment for AD.

Keywords: Alzheimer’s disease; Amla; anti-inflammatory; antioxidant; cardiovascular disease; type 2 diabetes.