Clonidine: placental transfer and neonatal adaption

Early Hum Dev. 1988 Aug-Sep;17(2-3):275-86.


The placental transfer of clonidine was investigated in five pregnancies. Clonidine readily crosses the placenta. The drug elimination in neonates was slow, but the only clinical abnormality was that of a raised arterial blood pressure. Hypertension for at least 24 h was observed in four cases. It is suggested that this may be related to a withdrawal syndrome due to the sudden cessation of the placentally transferred drug.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Clonidine / blood
  • Clonidine / pharmacokinetics*
  • Clonidine / therapeutic use
  • Female
  • Humans
  • Infant, Newborn / blood*
  • Maternal-Fetal Exchange*
  • Pre-Eclampsia / drug therapy*
  • Pregnancy


  • Clonidine