Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Feb 22.
doi: 10.1111/all.14247. Online ahead of print.

Orally Applied Bacterial Lysate in Infants at Risk for Atopy Does Not Prevent Atopic Dermatitis, Allergic Rhinitis, Asthma or Allergic Sensitization at School Age: Follow-up of a Randomized Trial

Affiliations

Orally Applied Bacterial Lysate in Infants at Risk for Atopy Does Not Prevent Atopic Dermatitis, Allergic Rhinitis, Asthma or Allergic Sensitization at School Age: Follow-up of a Randomized Trial

Siri Roßberg et al. Allergy. .

Abstract

Background: The allergy preventive effects of gut immune modulation by bacterial compounds are still not fully understood.

Objective: We sought to evaluate the effect of bacterial lysate applied orally from the second until seventh months of life on the prevalence of allergic diseases at school age.

Methods: In a randomized, placebo-controlled trial, 606 newborns with at least one allergic parent received orally a bacterial lysate consisting of heat-killed Gram-negative Escherichia coli Symbio and Gram-positive Enterococcus faecalis Symbio or placebo from week 5 until the end of month 7. A total of 402 children were followed until school age (6-11 years) for the assessment of current atopic dermatitis (AD), allergic rhinitis (AR), asthma and sensitization against aeroallergens.

Results: AD was diagnosed in 11.0% (22/200) of children in the active and in 10.4% (21/202) of children in the placebo group. AR was diagnosed in 35% (70/200) of children in the active and in 38.1% (77/202) children in the placebo group. Asthma was diagnosed in 9% (18/199) of children in the active and in 6.6% (13/197) of children in the placebo group. Sensitization occurred in 46.5% (66/142) of participants in the active and 51.7% (76/147) in the placebo group.

Conclusion: An oral bacterial lysate of heat-killed Gram-negative Escherichia coli and Gram-positive Enterococcus faecalis applied during the first 7 months of life did not influence the development of AD, asthma and AR at school age.

Keywords: asthma; atopic dermatitis; prevention; rhinitis.

Similar articles

See all similar articles

References

REFERENCES

    1. von Mutius E, Vercelli D. Farm living: effects on childhood asthma and allergy. Nature Rev Immunol. 2010;10(12):861-868.
    1. Ege MJ, Herzum I, Buchele G, et al. Prenatal exposure to a farm environment modifies atopic sensitization at birth. J Allergy Clin Immunol. 2008;122(2):407-412, 12 e1-4.
    1. Alfven T, Braun-Fahrlander C, Brunekreef B, et al. Allergic diseases and atopic sensitization in children related to farming and anthroposophic lifestyle-the PARSIFAL study. Allergy. 2006;61(4):414-421.
    1. Ege MJ. Intestinal microbial diversity in infancy and allergy risk at school age. J Allergy Clin Immunol. 2011;128(3):653-654.
    1. Ege M, Bieli C, Frei R, et al. Prenatal farm exposure is related to the expression of receptors of the innate immunity and to atopic sensitization in school-age children. J Allergy Clin Immunol. 2006;117(4):817-823.

LinkOut - more resources

Feedback