A new type of transforming growth factor-beta, TGF-beta 3

EMBO J. 1988 Dec 1;7(12):3737-43. doi: 10.1002/j.1460-2075.1988.tb03257.x.

Abstract

A new type of TGF-beta, TGF-beta 3, has been identified by cDNA characterization. The amino acid sequence of mature TGF-beta 3 and its precursor has been derived from porcine and human cDNA sequences. The human TGF-beta 3 gene is spread over seven exons as in the case of the TGF-beta 1 gene. Comparison with TGF-beta 1 and -beta 2 indicates a strong conservation of the mature sequences, but a relaxed homology in the precursor segments. TGF-beta 3 mRNA is mainly expressed in cell lines from mesenchymal origin, suggesting a biological role different from the other TGFs-beta.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Blotting, Northern
  • Cloning, Molecular
  • DNA / genetics
  • Genes
  • Humans
  • Introns
  • Molecular Sequence Data
  • Protein Precursors / genetics
  • RNA, Messenger / genetics
  • Swine
  • Transforming Growth Factors / classification*
  • Transforming Growth Factors / genetics

Substances

  • Protein Precursors
  • RNA, Messenger
  • Transforming Growth Factors
  • DNA