The Outline Structure of the T-cell Alpha Beta Receptor

EMBO J. 1988 Dec 1;7(12):3745-55.

Abstract

From an analysis of the immunoglobulins of known structure we derive a list of 40 sites crucial for the conserved structure of the variable domains. We show that, with marginal exceptions, the sequences of the T-cell alpha beta receptors contain, at sites homologous to these 40, the same or very similar residues. Thus the V alpha-V beta dimer has a framework structure very close to that of the immunoglobulins. Further comparisons show that parts of the surface of the V alpha-V beta framework are hypervariable. They also show that the loops that form the antigen-binding site are similar in size to those commonly found in the immunoglobulins but have different conformations. Only limited sequence variations occur in the first loop of the antigen-binding site in both V alpha and V beta. This, and their geometrical arrangement, suggest that they mainly interact with the MHC proteins.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Binding Sites
  • Humans
  • Immunoglobulin Variable Region / ultrastructure
  • Mice
  • Molecular Sequence Data
  • Protein Conformation
  • Receptors, Antigen, T-Cell / ultrastructure*

Substances

  • Immunoglobulin Variable Region
  • Receptors, Antigen, T-Cell