Effect of Nebulized Eucalyptus for Preventing Ventilator-associated Pneumonia in Patients Under Mechanical Ventilation: A Randomized Double Blind Clinical Trial

Altern Ther Health Med. 2020 Aug;26(S2):126-130.


Background: Pneumonia caused by the ventilator is the most common acquired infection in the intensive care unit (ICU), which increases the morbidity and mortality of the patients. Eucalyptus plant has antiseptic properties that may mollify such morbidity and mortality.

Objective: To assess the effect of Eucalyptus incense on prevention of pneumonia in patients with endotracheal tube in the ICU.

Research design: A randomized controlled clinical trial with parallel groups of 100 patients undergoing mechanical ventilation.

Setting: An ICU in a teaching hospital.

Interventions: Randomization to received Eucalyptus solution 5% (intervention group = 50) and received 10 cc distilled water as an inhaler 3 times/d (every 8 h/d for 20 min) (control group = 50).

Primary outcome measures: The incidence of early and delay pneumonia and pulmonary infections based on clinical pulmonary infection criteria were assessed.

Results: The incidence of late pneumonia was significantly lower in the intervention group compared with control groups (P < .01). The prevalence of Klebsiella, Candida albicans, and Staphylococcus aureus was significantly decreased in the intervention group (P < .01).

Conclusion: The results present study showed that Eucalyptus inhalation is effective in reducing the incidence of pulmonary infection in patients under ventilation.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Double-Blind Method
  • Eucalyptus*
  • Humans
  • Intensive Care Units
  • Pneumonia, Ventilator-Associated* / prevention & control
  • Respiration, Artificial / adverse effects