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. 2020 Feb 18;13(2):263-270.
doi: 10.18240/ijo.2020.02.10. eCollection 2020.

Altered spontaneous brain activity pattern in patients with ophthalmectomy: an resting-state fMRI study

Bing Zhang  1 , Biao Li  2 , Rong-Qiang Liu  3 , Yong-Qiang Shu  3 , You-Lan Min  2 , Qing Yuan  2 , Pei-Wen Zhu  2 , Qi Lin  2 , Lei Ye  2 , Yi Shao  2
Affiliations

Altered spontaneous brain activity pattern in patients with ophthalmectomy: an resting-state fMRI study

Bing Zhang et al. Int J Ophthalmol. .

Abstract

Aim: To use the voxel-wise degree centrality (DC) method to explore the underlying functional network brain-activity in patients with ophthalmectomy.

Methods: A total of 32 ophthalmic surgery patients (10 women and 22 men), and 32 healthy subjects (10 women and 22 men) highly matched in gender, age, and the same operation method. Everyone experienced a resting-state functional magnetic resonance imaging scan. The spontaneous brain activity could be assessed by DC. Correlation analysis was used to explore the relationships between the average DC signal values and behavior performance in different regions. Receiver operating characteristic (ROC) curve analysis was utilized to differentiate between ophthalmectomy patients and healthy controls (HCs).

Results: Compared with HCs, ophthalmectomy patients had greatly reduced DC values in left lingual gyrus, bilateral lingual lobe, left cingulate gyrus, and increased DC values of left cerebellum posterior lobe, left middle frontal gyrus1, right supramarginal gyrus, left middle frontal gyrus2, right middle frontal gyrus. However, we did not find that there was a correlation between the average DC values from various brain regions and clinical manifestations.

Conclusion: Dysfunction may be caused by ophthalmectomy in lots of cerebral areas, which may show the potential pathological mechanism of ophthalmectomy and it is beneficial to clinical diagnosis.

Keywords: degree centrality; ophthalmectomy; resting state; spontaneous brain activity.

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Figures

Figure 1
Figure 1. Significant differences of spontaneous brain activity between the ophthalmectomy group and healthy controls
The blue areas denote significantly reduced DC brain regions in the left lingual gyrus, bilateral lingual lobe, left cingulate gyrus. The red areas indicate that the left cerebellum posterior lobe, left middle frontal gyrus1, right supramarginal gyrus, left middle frontal gyrus2, and right middle frontal gyrus have higher DC cerebrum areas [P<0.05 for multiple comparisons using GRF theory (z>2.3, cluster-wise P<0.05 corrected)].
Figure 2
Figure 2. The mean values of altered DC values between the ophthalmectomy and HCs groups
Data are expressed as mean± standard deviation.
Figure 3
Figure 3. ROC curve analysis of the mean DC values for altered brain regions
The AUCs for DC values: LCPL: 0.773, LLG: 0.870, LMFG1: 0.867, BLL: 0.848, RSG: 0.842, LCG: 0.900, LMFG2: 0.873, RMFG: 0.864. LMFG: Left middle frontal gyrus; RMFG: Right middle frontal gyrus; LCPL: Left cerebellum posterior lobe; RSG: Right supramarginal gyrus; LLG: Left lingual gyrus; LCG: Left cingulate gyrus; BLL: Bilateral lingual lobe; AUC: Area under the curve.
Figure 4
Figure 4. The DC results of brain activity in ophthalmectomy group
Compared with the HCs, the DC of the brain areas in ophthalmectomy group were as follows: 1-right middle frontal gyrus (t=4.1662), 2-left middle frontal gyrus1 (t=4.5334), 3-left middle frontal gyrus2 (t=4.9024), 4-right supramarginal gyrus (t=4.6031), 5-left cerebellum posterior lobe (t=3.4195), 6-left lingual gyrus (t=-4.3060), 7-left cingulate gyrus (t=-5.0657) and 8-bilateral limbic lobe (t=-5.0474). The degree of quantitative changes is showed by the sizes of the spots.
Figure 5
Figure 5. DC method applied in ophthalmological diseases.
See this image and copyright information in PMC

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