Mass spectrometry reveals the assembly pathway of encapsulated ferritins and highlights a dynamic ferroxidase interface

Chem Commun (Camb). 2020 Mar 21;56(23):3417-3420. doi: 10.1039/c9cc08130e. Epub 2020 Feb 24.


Encapsulated ferritins (EncFtn) are a recently characterised member of the ferritin superfamily. EncFtn proteins are sequestered within encapsulin nanocompartments and form a unique biological iron storage system. Here, we use native mass spectrometry and hydrogen-deuterium exchange mass spectrometry to elucidate the metal-mediated assembly pathway of EncFtn.

MeSH terms

  • Ceruloplasmin / chemistry*
  • Ferritins / chemistry*
  • Mass Spectrometry / methods
  • Myxococcales / enzymology
  • Protein Multimerization


  • Ferritins
  • Ceruloplasmin

Supplementary concepts

  • Haliangium ochraceum