Identification of an Emergent Pathogen, Bartonella vinsonii, Using Next-Generation Sequencing in a Patient With Culture-Negative Endocarditis

J Pediatric Infect Dis Soc. 2021 Mar 26;10(2):213-216. doi: 10.1093/jpids/piaa014.


Diagnosis and treatment of culture negative endocarditis remains a challenge. This report describes a rare cause of endocarditis in humans, Bartonella vinsonii, identified through next generation sequencing of plasma microbial cell-free DNA with confirmation of cardiac valve tissue infection through immunohistochemical staining and polymerase chain reaction.

Keywords: Bartonella vinsonii; diagnostics; endocarditis; glomerulonephritis; next-generation sequencing.

MeSH terms

  • Bartonella
  • Bartonella Infections* / diagnosis
  • Bartonella Infections* / drug therapy
  • Endocarditis*
  • Endocarditis, Bacterial* / diagnosis
  • Endocarditis, Bacterial* / drug therapy
  • High-Throughput Nucleotide Sequencing
  • Humans

Supplementary concepts

  • Bartonella vinsonii