The use and evaluation of digital biomarkers, objective and quantifiable measures of biology, and health collected through digital devices is growing rapidly. To highlight some of the most promising work in the field, we have compiled a list of the top digital biomarkers papers from the past year. Eligible papers reported on original research that evaluated a digital sensor (e.g., smartphone, wearable sensor, implantable device) in humans and was published in a peer-reviewed journal in 2017. Nominations were solicited from the editorial board of Digital Biomarkers and supplemented by papers the editorial team identified from Web of Science, Google Scholar, and PubMed. The editorial board then selected up to ten papers to be recognized among 28 nominations. Here, we present all of the nominated papers and profile the eight that received the most votes. The top eight papers evaluated 1,290 individuals with digital pills, smartwatches, wearable devices, and electronic inhalers in disease states ranging from dementia to diabetes and from Parkinson disease to pain.
Keywords: Bipolar disorder; Chronic obstructive pulmonary disease; Digital divide; Digital pills; Huntington disease; Hypertension; Mental health; Parkinson disease; Passive monitoring; Wearable sensors.
Copyright © 2018 by S. Karger AG, Basel.
Conflict of interest statement
E. Ray Dorsey has received honoraria for speaking at American Academy of Neurology courses; received compensation for consulting activities from 23andMe, Clintrex, GlaxoSmithKline, Grand Rounds, Lundbeck, MC10, MedAvante, Medico Legal services, the National Institute of Neurological Disorders and Stroke, Shire, Teva, and UCB; received research support from AMC Health, Burroughs Wellcome Fund, Davis Phinney Foundation, Duke University, GlaxoSmithKlineGreat Lakes Neurotechnologies, Greater Rochester Health Foundation, Huntington Study Group, Michael J. Fox Foundation, National Science Foundation, Patient-Centered Outcomes Research Institute, Prana Biotechnology, Raptor Pharmaceuticals, Roche, Safra Foundation, University of California Irvine; and stock options from Grand Rounds. Christopher W. Snyder and Ashish Atreja have no conflicts of interest to disclose.
Current State of Digital Biomarker Technologies for Real-Life, Home-Based Monitoring of Cognitive Function for Mild Cognitive Impairment to Mild Alzheimer Disease and Implications for Clinical Care: Systematic Review.J Med Internet Res. 2019 Aug 30;21(8):e12785. doi: 10.2196/12785. J Med Internet Res. 2019. PMID: 31471958 Free PMC article. Review.
Advancing Artificial Intelligence in Sensors, Signals, and Imaging Informatics.Yearb Med Inform. 2019 Aug;28(1):115-117. doi: 10.1055/s-0039-1677943. Epub 2019 Aug 16. Yearb Med Inform. 2019. PMID: 31419823 Free PMC article. Review.
Quantification of Motor Function in Huntington Disease Patients Using Wearable Sensor Devices.Digit Biomark. 2019 Sep 6;3(3):103-115. doi: 10.1159/000502136. eCollection 2019 Sep-Dec. Digit Biomark. 2019. PMID: 32095771 Free PMC article.
Evaluation of smartphone-based testing to generate exploratory outcome measures in a phase 1 Parkinson's disease clinical trial.Mov Disord. 2018 Aug;33(8):1287-1297. doi: 10.1002/mds.27376. Epub 2018 Apr 27. Mov Disord. 2018. PMID: 29701258 Free PMC article. Clinical Trial.
Peer-selected "best papers"-are they really that "good"?PLoS One. 2015 Mar 19;10(3):e0118446. doi: 10.1371/journal.pone.0118446. eCollection 2015. PLoS One. 2015. PMID: 25789480 Free PMC article.