Systematic Comparison of Two Animal-to-Human Transmitted Human Coronaviruses: SARS-CoV-2 and SARS-CoV

Viruses. 2020 Feb 22;12(2):244. doi: 10.3390/v12020244.


After the outbreak of the severe acute respiratory syndrome (SARS) in the world in 2003, human coronaviruses (HCoVs) have been reported as pathogens that cause severe symptoms in respiratory tract infections. Recently, a new emerged HCoV isolated from the respiratory epithelium of unexplained pneumonia patients in the Wuhan seafood market caused a major disease outbreak and has been named the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This virus causes acute lung symptoms, leading to a condition that has been named as "coronavirus disease 2019" (COVID-19). The emergence of SARS-CoV-2 and of SARS-CoV caused widespread fear and concern and has threatened global health security. There are some similarities and differences in the epidemiology and clinical features between these two viruses and diseases that are caused by these viruses. The goal of this work is to systematically review and compare between SARS-CoV and SARS-CoV-2 in the context of their virus incubation, originations, diagnosis and treatment methods, genomic and proteomic sequences, and pathogenic mechanisms.

Keywords: SARS-CoV; SARS-CoV-2; clinical manifestations; coronaviruses; genomic comparison; pathogenic mechanism; proteomic comparison.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Betacoronavirus* / chemistry
  • Betacoronavirus* / genetics
  • Betacoronavirus* / pathogenicity
  • COVID-19
  • China / epidemiology
  • Chiroptera / virology
  • Coronavirus Infections* / diagnosis
  • Coronavirus Infections* / epidemiology
  • Coronavirus Infections* / therapy
  • Coronavirus Infections* / virology
  • Disease Reservoirs
  • Disease Susceptibility
  • Eutheria / virology
  • Genome, Viral
  • Global Health
  • Humans
  • Infectious Disease Incubation Period
  • Pneumonia, Viral* / diagnosis
  • Pneumonia, Viral* / epidemiology
  • Pneumonia, Viral* / therapy
  • Pneumonia, Viral* / virology
  • Proteome
  • SARS-CoV-2
  • Sequence Alignment
  • Severe Acute Respiratory Syndrome* / diagnosis
  • Severe Acute Respiratory Syndrome* / epidemiology
  • Severe Acute Respiratory Syndrome* / therapy
  • Severe Acute Respiratory Syndrome* / virology
  • Severe acute respiratory syndrome-related coronavirus* / chemistry
  • Severe acute respiratory syndrome-related coronavirus* / genetics
  • Severe acute respiratory syndrome-related coronavirus* / pathogenicity
  • Viral Proteins


  • Proteome
  • Viral Proteins