Licochalcone A in Combination with Salicylic Acid as Fluid Based and Hydroxy-Complex 10% Cream for the Treatment of Mild Acne: A Multicenter Prospective Trial

Federica Dall'Oglio; Gabriella Fabbrocini; Aurora Tedeschi; Marianna Donnarumma; Paolo Chiodini; Giuseppe Micali

doi:10.2147/CCID.S206935

Licochalcone A in Combination with Salicylic Acid as Fluid Based and Hydroxy-Complex 10% Cream for the Treatment of Mild Acne: A Multicenter Prospective Trial

Clin Cosmet Investig Dermatol. 2019 Dec 31:12:961-967. doi: 10.2147/CCID.S206935. eCollection 2019.

Authors

Federica Dall'Oglio¹, Gabriella Fabbrocini², Aurora Tedeschi¹, Marianna Donnarumma², Paolo Chiodini³, Giuseppe Micali¹

Affiliations

¹ Dermatology Clinic, University of Catania, Catania, Italy.
² Section of Dermatology, Department of Clinical Medicine and Surgery, University Federico II of Naples, Naples, Italy.
³ Medical Statistics Unit, University of Campania "Luigi Vanvitelli", Naples, Italy.

Abstract

Purpose: Topical cosmetic agents if correctly prescribed and used may improve outcomes in acne therapy. The aim of this study was to assess the efficacy and tolerability of a new daily cosmetic regimen in the treatment of mild facial acne.

Patients and methods: A multicenter, prospective, observational, clinical study was conducted on 91 adult patients with mild acne. Subjects were instructed to apply a fluid containing Licochalcone A/Salicylic acid/L-Carnitine in the morning and a cream with Licochalcone A/Hydroxy-Complex 10% at bedtime for 8 weeks. The efficacy was clinically evaluated by Global Acne Grading System (GAGS) score and by comedones/papules lesions count and by instrumental assessment (Sebutape^TMand Reveal Photo Imager/VISIA-CR™ imaging) at baseline, at 4 and 8 weeks.

Results: At 4 weeks a statistically significant reduction from baseline of GAGSwas observed. In addition, the mean total count of comedones and papules was significantly reduced by 41% and 45%, respectively, from baseline along with a significant reduction of mean sebum of 47%. At 8 weeks, a further statistically significant reduction from baseline of GAGS, total count of comedones and papules (64% and 71%, respectively), along with an additional sebum reduction of about 52% was also recorded.

Conclusion: Our results suggest that the daily regimen based on Licochalcone A with Salicylic acid/L-Carnitine as fluid or with Hydroxy-Complex 10% as cream represent an interesting cosmetic approach for treating mild acne.

Keywords: hydroxyl-complex; licochalcone A; mild acne; salicylic acid; topical cosmetic.