A familial risk of chronic renal failure among blacks on dialysis?

J Clin Epidemiol. 1988;41(12):1189-96. doi: 10.1016/0895-4356(88)90023-6.


End-stage renal disease (ESRD) is strongly associated with both hypertension and diabetes. As both diabetes and hypertension tend to be familial, we hypothesized a familial clustering of ESRD cases. Using 114 cases from three dialysis centers and 99 controls, the exposure odds ratio was determined. Mantel-Haenszel analysis demonstrated that individual history of hypertension (ORmh = 5.14; 95% Cl = 2.29-11.56) and history of chronic renal failure in a first or second degree relative (chi 2mh = 5.12; p less than 0.05) were significant "risk" factors for being dialysed for ESRD, while family history of hypertension posed a more questionable risk (ORmh = 1.92 95% Cl 0.96-3.86). In fact, when the subset of patients identified with hypertensive renal disease was considered independently, the risk due to family history of hypertension increased 14-fold which suggests a role as a confounder for hypertensive renal disease. The effect of chronic renal failure in a relative was independent of family history of diabetes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • African Continental Ancestry Group*
  • Diabetes Complications
  • Diabetes Mellitus / diagnosis
  • Diabetes Mellitus / epidemiology
  • Epidemiologic Methods
  • Female
  • Humans
  • Hypertension / complications
  • Hypertension / diagnosis
  • Hypertension / drug therapy
  • Hypertension / epidemiology
  • Kidney Failure, Chronic / epidemiology
  • Kidney Failure, Chronic / etiology
  • Kidney Failure, Chronic / genetics*
  • Los Angeles
  • Male
  • Middle Aged
  • Renal Dialysis*
  • Risk Factors