Nanoparticle-Based Delivery of Tumor Suppressor microRNA for Cancer Therapy

Cells. 2020 Feb 24;9(2):521. doi: 10.3390/cells9020521.


Improved understanding of microRNA expression and function in cancer has revealed a range of microRNAs that negatively regulate many oncogenic pathways, thus representing potent tumor suppressors. Therapeutic targeting of the expression of these microRNAs to the site of tumors and metastases provides a promising avenue for cancer therapy. To overcome challenges associated with microRNA degradation, transient expression and poor targeting, novel nanoparticles are being developed and employed to shield microRNAs for tumor-targeted delivery. This review focuses on studies describing a variety of both natural and synthetic nanoparticle delivery vehicles that have been engineered for tumor-targeted delivery of tumor suppressor microRNAs in vivo.

Keywords: cancer therapy; nanoparticle delivery; tumor suppressor miRNA.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antineoplastic Agents / administration & dosage*
  • Dendrimers / administration & dosage*
  • Dendrimers / chemistry
  • Extracellular Vesicles
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Liposomes / administration & dosage*
  • Mice
  • MicroRNAs / administration & dosage*
  • MicroRNAs / genetics
  • MicroRNAs / metabolism
  • Molecular Targeted Therapy / methods
  • Nanoparticles / administration & dosage*
  • Neoplasms / drug therapy*
  • Neoplasms / genetics
  • Neoplasms / metabolism
  • Polyamines
  • Xenograft Model Antitumor Assays


  • Antineoplastic Agents
  • Dendrimers
  • Lipid Nanoparticles
  • Liposomes
  • MicroRNAs
  • Poly(amidoamine)
  • Polyamines