[Fundamental and clinical evaluation of imipenem/cilastatin sodium in the perinatal period]

Jpn J Antibiot. 1988 Nov;41(11):1778-85.
[Article in Japanese]


To evaluate the efficacy of imipenem/cilastatin sodium (IPM/CS) in the field of obstetrics and gynecology, fundamental (measurement of IPM/CS concentrations in mothers' milk) and clinical studies were performed. Concentrations of IPM/CS in mothers' milk were measured every 1 hour up to 6 hours after a 30-minute drip infusion of 500 mg/500 mg of IPM/CS. IPM/CS was distributed similarly to other cephalosporins. In the clinical study, a 500 mg/500 mg dose of IPM/CS was administered to 5 patients with puerperal intrauterine infections and to 3 patients with urinary tract infections by a 30-minute drip infusion b.i.d. or t.i.d. Good responses were observed in all 8 patients, though the infections were mild or moderate. From these results, IPM/CS appeared to be a useful drug for the treatment of perinatal infections.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Adult
  • Bacterial Infections / drug therapy*
  • Chemical Phenomena
  • Chemistry
  • Cilastatin / administration & dosage*
  • Cilastatin / pharmacokinetics
  • Cilastatin / therapeutic use
  • Drug Evaluation
  • Drug Therapy, Combination / pharmacokinetics
  • Drug Therapy, Combination / therapeutic use
  • Endometritis / drug therapy
  • Female
  • Humans
  • Imipenem / administration & dosage*
  • Imipenem / pharmacokinetics
  • Imipenem / therapeutic use
  • Infusions, Intravenous
  • Lactation / metabolism
  • Milk, Human / metabolism
  • Pregnancy
  • Pregnancy Complications, Infectious / drug therapy*
  • Puerperal Infection / drug therapy*
  • Urinary Tract Infections / drug therapy


  • Cilastatin
  • Imipenem