Template-guided selection of RNA ligands using imine-based dynamic combinatorial chemistry

Chem Commun (Camb). 2020 Mar 24;56(24):3555-3558. doi: 10.1039/d0cc00266f.


This study establishes the applicability of imine-based dynamic combinatorial chemistry to discover non-covalent ligands for RNA targets. We elucidate properties underlying the reactivity of arylamines and demonstrate target-guided amplification of tight binders in an amiloride-based dynamic library.

MeSH terms

  • Amines / chemistry
  • Combinatorial Chemistry Techniques
  • Genes, env
  • HIV Long Terminal Repeat
  • Imines / chemistry*
  • Ligands
  • RNA / chemistry*


  • Amines
  • Imines
  • Ligands
  • RNA