Antimicrobial host defence peptides: functions and clinical potential

doi:10.1038/s41573-019-0058-8

Review

. 2020 May;19(5):311-332.

doi: 10.1038/s41573-019-0058-8. Epub 2020 Feb 27.

Antimicrobial host defence peptides: functions and clinical potential

Neeloffer Mookherjee¹, Marilyn A Anderson², Henk P Haagsman³, Donald J Davidson⁴

Affiliations

¹ Manitoba Centre for Proteomics and Systems Biology, Department of Internal Medicine and Department of Immunology, University of Manitoba, Winnipeg, Manitoba, Canada. neeloffer.mookherjee@umanitoba.ca.
² La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, Australia.
³ Division of Molecular Host Defence, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands.
⁴ University of Edinburgh Centre for Inflammation Research, Queen's Medical Research Institute, Edinburgh, UK.

PMID: 32107480
DOI: 10.1038/s41573-019-0058-8

Review

Antimicrobial host defence peptides: functions and clinical potential

Neeloffer Mookherjee et al. Nat Rev Drug Discov. 2020 May.

. 2020 May;19(5):311-332.

doi: 10.1038/s41573-019-0058-8. Epub 2020 Feb 27.

Authors

Neeloffer Mookherjee¹, Marilyn A Anderson², Henk P Haagsman³, Donald J Davidson⁴

Affiliations

¹ Manitoba Centre for Proteomics and Systems Biology, Department of Internal Medicine and Department of Immunology, University of Manitoba, Winnipeg, Manitoba, Canada. neeloffer.mookherjee@umanitoba.ca.
² La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, Australia.
³ Division of Molecular Host Defence, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands.
⁴ University of Edinburgh Centre for Inflammation Research, Queen's Medical Research Institute, Edinburgh, UK.

PMID: 32107480
DOI: 10.1038/s41573-019-0058-8

Abstract

Cationic host defence peptides (CHDP), also known as antimicrobial peptides, are naturally occurring peptides that can combat infections through their direct microbicidal properties and/or by influencing the host's immune responses. The unique ability of CHDP to control infections as well as resolve harmful inflammation has generated interest in harnessing the properties of these peptides to develop new therapies for infectious diseases, chronic inflammatory disorders and wound healing. Various strategies have been used to design synthetic optimized peptides, with negligible toxicity. Here, we focus on the progress made in understanding the scope of functions of CHDP and the emerging potential clinical applications of CHDP-based therapies.

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References

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[1] Iannella, H., Luna, C. & Waterer, G. Inhaled corticosteroids and the increased risk of pneumonia: what’s new? A 2015 updated review. Ther. Adv. Respir. Dis. 10, 235–255 (2016). - PubMed - PMC

[2] Iannella, H., Luna, C. & Waterer, G. Inhaled corticosteroids and the increased risk of pneumonia: what’s new? A 2015 updated review. Ther. Adv. Respir. Dis. 10, 235–255 (2016). - PubMed - PMC

[3] Widdifield, J. et al. Serious infections in a population-based cohort of 86,039 seniors with rheumatoid arthritis. Arthritis Care Res. 65, 353–361 (2013).

[4] Widdifield, J. et al. Serious infections in a population-based cohort of 86,039 seniors with rheumatoid arthritis. Arthritis Care Res. 65, 353–361 (2013).

[5] Clancy, C. J. et al. Emerging and resistant infections. Ann. Am. Thorac. Soc. 11, S193–S200 (2014). - PubMed - PMC

[6] Clancy, C. J. et al. Emerging and resistant infections. Ann. Am. Thorac. Soc. 11, S193–S200 (2014). - PubMed - PMC

[7] Simmaco, M., Kreil, G. & Barra, D. Bombinins, antimicrobial peptides from Bombina species. Biochim. Biophys. Acta 1788, 1551–1555 (2009). - PubMed

[8] Simmaco, M., Kreil, G. & Barra, D. Bombinins, antimicrobial peptides from Bombina species. Biochim. Biophys. Acta 1788, 1551–1555 (2009). - PubMed

[9] Steiner, H., Hultmark, D., Engstrom, A., Bennich, H. & Boman, H. G. Sequence and specificity of two antibacterial proteins involved in insect immunity. Nature 292, 246–248 (1981). - PubMed

[10] Steiner, H., Hultmark, D., Engstrom, A., Bennich, H. & Boman, H. G. Sequence and specificity of two antibacterial proteins involved in insect immunity. Nature 292, 246–248 (1981). - PubMed

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Antimicrobial host defence peptides: functions and clinical potential

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Antimicrobial host defence peptides: functions and clinical potential

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