Dendrotoxin-sensitive K+ channels in dorsal root ganglion cells

Neurosci Lett. 1988 Oct 31;93(1):49-55. doi: 10.1016/0304-3940(88)90011-0.


In primary sensory cells, a K current active at resting potential is selectively blocked by the convulsant snake toxin, dendrotoxin. Using the patch-clamp technique, we have examined the characteristics of this K current at the unitary level. The voltage-activated K+ channels were found to have a maximum conductance of 5-10 pS in a 'physiological' K+ gradient. They show negligible sensitivity to calcium at the inner membrane aspect. Blockade by dendrotoxin seems likely to be due to direct action on the K+ channel.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Elapid Venoms / pharmacology*
  • Electric Stimulation
  • Ganglia, Spinal / drug effects
  • Ganglia, Spinal / physiology*
  • In Vitro Techniques
  • Membrane Potentials / drug effects
  • Neurons, Afferent / drug effects
  • Neurons, Afferent / physiology*
  • Potassium Channels / physiology*
  • Rats


  • Elapid Venoms
  • Potassium Channels
  • dendrotoxin