Fetal cardiac interventions: Where do we stand?

Arch Cardiovasc Dis. 2020 Feb;113(2):121-128. doi: 10.1016/j.acvd.2019.06.007. Epub 2020 Feb 26.


Fetal cardiac intervention (FCI) is a novel and evolving technique that allows for in utero treatment of a subset of congenital heart disease. This review describes the rationale, selection criteria, technical features, and current outcomes for the three most commonly performed FCI: fetal aortic stenosis with evolving hypoplastic left heart syndrome (HLHS); HLHS with intact or restrictive atrial septum; and pulmonary atresia with intact ventricular septum, with concern for worsening right ventricular (RV) hypoplasia.

Keywords: Aortic stenosis; Cardiologie fœtale; Cathétérisme interventionnel; Fetal cardiology; Hypoplasie du ventricule gauche; Hypoplastic left heart syndrome; Sténose aortique; Transcatheter intervention.

Publication types

  • Review

MeSH terms

  • Aortic Valve Stenosis / diagnostic imaging
  • Aortic Valve Stenosis / physiopathology
  • Aortic Valve Stenosis / therapy
  • Cardiac Catheterization* / adverse effects
  • Cardiac Surgical Procedures* / adverse effects
  • Echocardiography
  • Female
  • Fetal Heart / abnormalities
  • Fetal Heart / diagnostic imaging
  • Fetal Heart / physiopathology
  • Fetal Heart / surgery*
  • Fetal Therapies* / adverse effects
  • Gestational Age
  • Heart Defects, Congenital / diagnostic imaging
  • Heart Defects, Congenital / physiopathology
  • Heart Defects, Congenital / therapy*
  • Humans
  • Hypoplastic Left Heart Syndrome / diagnostic imaging
  • Hypoplastic Left Heart Syndrome / physiopathology
  • Hypoplastic Left Heart Syndrome / therapy
  • Pregnancy
  • Pulmonary Atresia / diagnostic imaging
  • Pulmonary Atresia / physiopathology
  • Pulmonary Atresia / therapy
  • Risk Factors
  • Treatment Outcome
  • Ultrasonography, Prenatal

Supplementary concepts

  • Pulmonary Atresia with Intact Ventricular Septum