Effects of Grape Seed Proanthocyanidin Extract on Obesity

Obes Facts. 2020;13(2):279-291. doi: 10.1159/000502235. Epub 2020 Feb 28.


Obesity is a chronic metabolic disease resulting from excessive fat accumulation and/or abnormal distribution caused by multiple factors. As a major component of metabolic syndrome, obesity is closely related to many diseases such as type 2 diabetes mellitus, hyperlipidemia, hypertension, coronary heart disease, stroke and cancer. Hence, the problem of obesity cannot be ignored, and recent studies have shown that grape seed proanthocyanidin extract (GSPE) has an antiobesity effect. This paper systematically reviews the research progress and potential mechanism of GSPE emphasizing on obesity prevention and treatment.

Keywords: Grape seed proanthocyanidin extract; Mechanism; Obesity.

Publication types

  • Research Support, Non-U.S. Gov't
  • Systematic Review

MeSH terms

  • Animals
  • Diabetes Mellitus, Type 2 / drug therapy
  • Grape Seed Extract / pharmacology*
  • Grape Seed Extract / therapeutic use*
  • Humans
  • Metabolic Syndrome / drug therapy
  • Obesity / drug therapy*
  • Phytotherapy / methods
  • Plant Extracts / pharmacology
  • Proanthocyanidins / pharmacology*
  • Proanthocyanidins / therapeutic use*
  • Weight Loss / drug effects


  • Grape Seed Extract
  • Grape Seed Proanthocyanidins
  • Plant Extracts
  • Proanthocyanidins
  • proanthocyanidin