[Advances in the research of mechanism and related immunotherapy on the cytokine storm induced by coronavirus disease 2019]

Zhonghua Shao Shang Za Zhi. 2020 Jun 20;36(6):471-475. doi: 10.3760/cma.j.cn501120-20200224-00088.
[Article in Chinese]

Abstract

Coronavirus disease 2019 (COVID-19) has seriously affected the safety of patients and social stability. Some COVID-19 patients in the later stage of disease may develop into acute respiratory distress syndrome or even multiple organ failure. However, one of the most important mechanisms underlying the deterioration of disease is cytokine storm. At present, some therapies such as interleukin-6 antibody blocker, stem cell therapy, and transfusion of convalescent plasma have been applied to counteract the cytokine storm with some progresses being achieved. This article reviews the influences of cytokine storm syndrome on the COVID-19 and the corresponding immunotherapies to resist cytokine storm.

新型冠状病毒肺炎(COVID-19)已严重影响了患者的生命安全和社会稳定。部分COVID-19患者在疾病后期可发展为急性呼吸窘迫综合征甚至多器官功能衰竭,而导致这一病情转变潜在的重要机制就是细胞因子风暴的产生。目前,白细胞介素6抗体阻断剂、干细胞疗法和回输康复患者血清等方法缓解细胞因子风暴已取得一定进展。本文就细胞因子风暴对COVID-19的影响及抵抗细胞因子风暴的免疫治疗方法进行综述。.

Keywords: Coronavirus disease 2019; Cytokine storm; Cytokines; Immune system; Immunotherapy.

Publication types

  • Review

MeSH terms

  • Antibodies / therapeutic use
  • Betacoronavirus
  • COVID-19
  • Coronavirus Infections / immunology*
  • Coronavirus Infections / therapy*
  • Cytokine Release Syndrome / therapy*
  • Cytokine Release Syndrome / virology
  • Humans
  • Immunization, Passive
  • Immunotherapy*
  • Interleukin-6 / antagonists & inhibitors
  • Pandemics
  • Pneumonia, Viral / immunology*
  • Pneumonia, Viral / therapy*
  • SARS-CoV-2
  • Stem Cell Transplantation

Substances

  • Antibodies
  • IL6 protein, human
  • Interleukin-6

Supplementary concepts

  • COVID-19 serotherapy