[Advances in the research of mechanism and related immunotherapy on the cytokine storm induced by coronavirus disease 2019]

Zhonghua Shao Shang Za Zhi. 2020 Jun 20;36(6):471-475. doi: 10.3760/cma.j.cn501120-20200224-00088.
[Article in Chinese]


Coronavirus disease 2019 (COVID-19) has seriously affected the safety of patients and social stability. Some COVID-19 patients in the later stage of disease may develop into acute respiratory distress syndrome or even multiple organ failure. However, one of the most important mechanisms underlying the deterioration of disease is cytokine storm. At present, some therapies such as interleukin-6 antibody blocker, stem cell therapy, and transfusion of convalescent plasma have been applied to counteract the cytokine storm with some progresses being achieved. This article reviews the influences of cytokine storm syndrome on the COVID-19 and the corresponding immunotherapies to resist cytokine storm.


Keywords: Coronavirus disease 2019; Cytokine storm; Cytokines; Immune system; Immunotherapy.

Publication types

  • Review

MeSH terms

  • Antibodies / therapeutic use
  • Betacoronavirus
  • COVID-19
  • Coronavirus Infections / immunology*
  • Coronavirus Infections / therapy*
  • Cytokine Release Syndrome / therapy*
  • Cytokine Release Syndrome / virology
  • Humans
  • Immunization, Passive
  • Immunotherapy*
  • Interleukin-6 / antagonists & inhibitors
  • Pandemics
  • Pneumonia, Viral / immunology*
  • Pneumonia, Viral / therapy*
  • SARS-CoV-2
  • Stem Cell Transplantation


  • Antibodies
  • IL6 protein, human
  • Interleukin-6

Supplementary concepts

  • COVID-19 serotherapy