The Incretin Concept Today

Diabetologia. 1979 Feb;16(2):75-85. doi: 10.1007/BF01225454.

Abstract

1. The insulinogenic factor of the gastrointestinal mucosa named "incretin" is only one part of the complex enteroinsular axis. --2. Of the chemically defined gastrointestinal hormones GIP is the strongest incretin candidate. --3. Because of the dual function of GIP as gastrone and insulinotropic substance several safeguards against GIP-mediated insulin hypoglycaemia exist. --4. No pathological condition has yet been found which is causally related to hyper- or hyposecretion of GIP. However, an exaggerated GIP response (usually secondary to the disease) may participate in the pathogenesis of hyperinsulinaemia of patients with obesity and duodenal ulcer. --5. The injection of GIP antibodies only partially abolishes the incretin effect. Therefore, GIP, although important, is not the only incretin.

Publication types

  • Review

MeSH terms

  • Absorption
  • Diabetes Mellitus / metabolism
  • Feedback
  • Gastrins / physiology
  • Gastrointestinal Hormones / physiology*
  • Humans
  • Insulin / metabolism*
  • Insulin Secretion
  • Neurotransmitter Agents
  • Obesity / metabolism
  • Peptides
  • Vagus Nerve / physiology*

Substances

  • Gastrins
  • Gastrointestinal Hormones
  • Insulin
  • Neurotransmitter Agents
  • Peptides