Recurrent Pregnancy Loss

In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan.


Recurrent pregnancy loss (RPL) is defined in the United States as two or more consecutive failed clinical pregnancies documented by ultrasound or histopathology. In the United Kingdom, it is defined as having three or more consecutive early pregnancy losses.

Only about 2 percent of pregnant women have two consecutive pregnancy losses. Up to 50 percent of patients with RPL have no clearly defined etiology. RPL is one of the complex and challenging scenarios in reproductive medicine, and it is frustrating for the patients, their families, and treating physicians. When the etiology of RPL is unclear, it can create anxiety and apprehension among the patients.

RPL can be categorized into primary and secondary; primary RPL refers to pregnancy loss in women who never had a live birth. In contrast, secondary RPL is defined as pregnancy loss in women who had a previous live birth.

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