In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan.


Minocycline belongs to the tetracycline class of antibiotics and is used to manage and treat both infectious and non-infectious conditions. In addition to its effectiveness against both gram-positive and gram-negative bacteria, minocycline also exhibits anti-inflammatory, antioxidant, anti-apoptotic, and immunomodulatory properties. Furthermore, this medication is recognized as the most effective tetracycline derivative in terms of its ability to provide neuroprotective effects. This activity describes minocycline's mechanism of action, indications, and contraindications as a valuable agent in treating and managing bacterial infections and conditions such as acne, neurodegenerative diseases, periodontitis, and dermatitis. This activity also highlights the adverse event profile, dosing, pharmacodynamics, pharmacokinetics, monitoring, and other relevant interactions of minocycline. These are crucial considerations for healthcare professionals engaged in treating patients with the conditions mentioned above.

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