Imaging manifestations of immune-related adverse effects in checkpoint inhibitor therapies: A primer for the radiologist

Abstract

Immune checkpoint inhibitors are monoclonal antibodies directed against cellular pathways on T-cells to treat different types of malignancies. This new therapy can cause immune-related adverse events that can involve almost any organ system. This article will review clinical presentations, molecular mechanisms and imaging manifestations of adverse events caused by checkpoint inhibitors and also illustrate the pseudoprogression tumor response pattern.

Keywords: Checkpoint inhibitors; Immune-related adverse events; Immunotherapy; Pseudoprogression.