Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target

Intensive Care Med. 2020 Apr;46(4):586-590. doi: 10.1007/s00134-020-05985-9. Epub 2020 Mar 3.
No abstract available

MeSH terms

  • Alveolar Epithelial Cells / metabolism*
  • Betacoronavirus
  • Humans
  • Peptidyl-Dipeptidase A*
  • RNA, Viral
  • Receptors, Virus / metabolism*
  • Respiratory Distress Syndrome, Adult / drug therapy*
  • Severe Acute Respiratory Syndrome / complications
  • Severe Acute Respiratory Syndrome / enzymology*
  • Severe Acute Respiratory Syndrome / virology
  • Spike Glycoprotein, Coronavirus*
  • Viral Envelope Proteins / metabolism

Substances

  • RNA, Viral
  • Receptors, Virus
  • Spike Glycoprotein, Coronavirus
  • Viral Envelope Proteins
  • spike protein, SARS-CoV-2
  • Peptidyl-Dipeptidase A
  • angiotensin converting enzyme 2

Supplementary concepts

  • severe acute respiratory syndrome coronavirus 2