Positive association of SCD1 genetic variation and metabolic syndrome in dialysis patients in China

Per Med. 2020 Mar;17(2):111-119. doi: 10.2217/pme-2019-0020. Epub 2020 Mar 3.


Aim: Metabolic syndrome (MetS) diagnosed in the dialysis patients is increasingly reported which worsens the prognosis of the renal diseases. The relationship of SCD1 with MetS is largely unknown. The purpose of this study was to investigate the relationship between SCD1 polymorphism and MetS in dialysis patients. Methods: A cross-sectional study was conducted on 323 Chinese dialysis patients, and the correlation between the seven SNPs of SCD1 gene (rs10883465, rs2060792, rs1502593, rs522951, rs3071, rs3978768 and rs1393492) and MetS was analyzed. Results: One tag-SNP (rs1393492) has significantly associated with the prevalence of MetS. Dialysis patients with rs1393492 AA genotype of SCD1 are more prone to MetS (p = 0.021). Conclusion: This study shows that the rs1393492 variations of SCD1 gene are related with the development of MetS in Chinese dialysis patients.

Keywords: dialysis; inflammation; lipid metabolism; metabolic syndrome; polymorphism; stearoyl-CoA desaturase 1.

MeSH terms

  • Adult
  • Aged
  • China / epidemiology
  • Cross-Sectional Studies
  • Female
  • Humans
  • Kidney Diseases / therapy*
  • Male
  • Metabolic Syndrome / epidemiology*
  • Metabolic Syndrome / genetics
  • Middle Aged
  • Polymorphism, Single Nucleotide*
  • Prevalence
  • Renal Dialysis
  • Stearoyl-CoA Desaturase / genetics*


  • SCD1 protein, human
  • Stearoyl-CoA Desaturase