Microbiome Modulation of the Host Adaptive Immunity through Bile Acid Modification

Cell Metab. 2020 Mar 3;31(3):445-447. doi: 10.1016/j.cmet.2020.02.006.


The microbiome is well known to influence the immune response of the host. Song et al. now show that the microbiome modulates adaptive immunity in mice through formation of bile acid species acting on RORγ+ regulatory T cells via the Vitamin D Receptor, thereby lowering the vulnerability for chemically induced colitis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Adaptive Immunity
  • Animals
  • Bile
  • Gastrointestinal Microbiome*
  • Homeostasis
  • Mice
  • Microbiota*
  • Nuclear Receptor Subfamily 1, Group F, Member 3
  • T-Lymphocytes, Regulatory


  • Nuclear Receptor Subfamily 1, Group F, Member 3