A Structural Understanding of Class B GPCR Selectivity and Activation Revealed

Brian Krumm; Bryan L Roth

doi:10.1016/j.str.2020.02.004

A Structural Understanding of Class B GPCR Selectivity and Activation Revealed

Structure. 2020 Mar 3;28(3):277-279. doi: 10.1016/j.str.2020.02.004.

Authors

Brian Krumm¹, Bryan L Roth²

Affiliations

¹ Department of Pharmacology, University of North Carolina Chapel Hill Medical School, Chapel Hill, NC 27514, USA.
² Department of Pharmacology, University of North Carolina Chapel Hill Medical School, Chapel Hill, NC 27514, USA. Electronic address: bryan_roth@med.unc.edu.

PMID: 32130889
DOI: 10.1016/j.str.2020.02.004

Abstract

Ma et al. (2020) and Liang et al. (2020) describe the cryo-EM structures of three class B G protein-coupled receptors (GPCRs) in complex with native peptides and Gs. Their work establishes the structural basis of peptide specificity and a conserved mechanism of receptor activation and G protein coupling for class B GPCRs.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Cryoelectron Microscopy
GTP-Binding Proteins*
Peptides
Receptors, G-Protein-Coupled*

Substances

Peptides
Receptors, G-Protein-Coupled
GTP-Binding Proteins