A potential role for integrins in host cell entry by SARS-CoV-2

Antiviral Res. 2020 May;177:104759. doi: 10.1016/j.antiviral.2020.104759. Epub 2020 Mar 1.

Abstract

  1. Integrin may act as an alternative receptor for SARS-CoV-2 and could be implicated in its transmission and pathology.

  2. The spike protein of SARS-CoV-2 acquired a RGD motif known to bind integrins. This motif is absent from other coronaviruses.

  3. The integrin-binding motif is present at the surface of the spike protein, close to the ACE2 receptor-binding region.

  4. Integrin binding may be a promising therapeutics target, and should be tested experimentally.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Betacoronavirus / metabolism*
  • COVID-19
  • Coronavirus Infections / physiopathology*
  • Coronavirus Infections / virology
  • Drug Delivery Systems
  • Host-Pathogen Interactions / physiology*
  • Humans
  • Integrins / metabolism*
  • Pandemics
  • Pneumonia, Viral / physiopathology*
  • Pneumonia, Viral / virology
  • Protein Binding
  • Protein Interaction Domains and Motifs
  • SARS-CoV-2
  • Spike Glycoprotein, Coronavirus / chemistry
  • Spike Glycoprotein, Coronavirus / metabolism
  • Virus Internalization*

Substances

  • Integrins
  • Spike Glycoprotein, Coronavirus
  • spike protein, SARS-CoV-2