Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 2020 Mar 6;367(6482):eaay5947.
doi: 10.1126/science.aay5947.

An atlas of the protein-coding genes in the human, pig, and mouse brain

Evelina Sjöstedt  1   2 , Wen Zhong  2 , Linn Fagerberg  2 , Max Karlsson  2 , Nicholas Mitsios  1 , Csaba Adori  1 , Per Oksvold  2 , Fredrik Edfors  2 , Agnieszka Limiszewska  1 , Feria Hikmet  3 , Jinrong Huang  4   5   6   7 , Yutao Du  5   8 , Lin Lin  4   6 , Zhanying Dong  4   5   6 , Ling Yang  4   5   6 , Xin Liu  5   8 , Hui Jiang  9 , Xun Xu  5   8 , Jian Wang  5   8 , Huanming Yang  5   8 , Lars Bolund  4   5   6 , Adil Mardinoglu  2 , Cheng Zhang  2 , Kalle von Feilitzen  2 , Cecilia Lindskog  3 , Fredrik Pontén  3 , Yonglun Luo  4   5   6 , Tomas Hökfelt  1 , Mathias Uhlén  10   2 , Jan Mulder  10
Affiliations
Comparative Study

An atlas of the protein-coding genes in the human, pig, and mouse brain

Evelina Sjöstedt et al. Science. .

Abstract

The brain, with its diverse physiology and intricate cellular organization, is the most complex organ of the mammalian body. To expand our basic understanding of the neurobiology of the brain and its diseases, we performed a comprehensive molecular dissection of 10 major brain regions and multiple subregions using a variety of transcriptomics methods and antibody-based mapping. This analysis was carried out in the human, pig, and mouse brain to allow the identification of regional expression profiles, as well as to study similarities and differences in expression levels between the three species. The resulting data have been made available in an open-access Brain Atlas resource, part of the Human Protein Atlas, to allow exploration and comparison of the expression of individual protein-coding genes in various parts of the mammalian brain.

PubMed Disclaimer

Similar articles

  • Visualizing the spatial gene expression organization in the brain through non-linear similarity embeddings.
    Mahfouz A, van de Giessen M, van der Maaten L, Huisman S, Reinders M, Hawrylycz MJ, Lelieveldt BP. Mahfouz A, et al. Methods. 2015 Feb;73:79-89. doi: 10.1016/j.ymeth.2014.10.004. Epub 2014 Oct 16. Methods. 2015. PMID: 25449901
  • A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
    Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A. Diez-Roux G, et al. PLoS Biol. 2011 Jan 18;9(1):e1000582. doi: 10.1371/journal.pbio.1000582. PLoS Biol. 2011. PMID: 21267068 Free PMC article.
  • A transcriptomic and epigenomic cell atlas of the mouse primary motor cortex.
    Yao Z, Liu H, Xie F, Fischer S, Adkins RS, Aldridge AI, Ament SA, Bartlett A, Behrens MM, Van den Berge K, Bertagnolli D, de Bézieux HR, Biancalani T, Booeshaghi AS, Bravo HC, Casper T, Colantuoni C, Crabtree J, Creasy H, Crichton K, Crow M, Dee N, Dougherty EL, Doyle WI, Dudoit S, Fang R, Felix V, Fong O, Giglio M, Goldy J, Hawrylycz M, Herb BR, Hertzano R, Hou X, Hu Q, Kancherla J, Kroll M, Lathia K, Li YE, Lucero JD, Luo C, Mahurkar A, McMillen D, Nadaf NM, Nery JR, Nguyen TN, Niu SY, Ntranos V, Orvis J, Osteen JK, Pham T, Pinto-Duarte A, Poirion O, Preissl S, Purdom E, Rimorin C, Risso D, Rivkin AC, Smith K, Street K, Sulc J, Svensson V, Tieu M, Torkelson A, Tung H, Vaishnav ED, Vanderburg CR, van Velthoven C, Wang X, White OR, Huang ZJ, Kharchenko PV, Pachter L, Ngai J, Regev A, Tasic B, Welch JD, Gillis J, Macosko EZ, Ren B, Ecker JR, Zeng H, Mukamel EA. Yao Z, et al. Nature. 2021 Oct;598(7879):103-110. doi: 10.1038/s41586-021-03500-8. Epub 2021 Oct 6. Nature. 2021. PMID: 34616066 Free PMC article.
  • Neuroinformatics of the Allen Mouse Brain Connectivity Atlas.
    Kuan L, Li Y, Lau C, Feng D, Bernard A, Sunkin SM, Zeng H, Dang C, Hawrylycz M, Ng L. Kuan L, et al. Methods. 2015 Feb;73:4-17. doi: 10.1016/j.ymeth.2014.12.013. Epub 2014 Dec 20. Methods. 2015. PMID: 25536338 Review.
  • The Allen Brain Atlas: 5 years and beyond.
    Jones AR, Overly CC, Sunkin SM. Jones AR, et al. Nat Rev Neurosci. 2009 Nov;10(11):821-8. doi: 10.1038/nrn2722. Epub 2009 Oct 14. Nat Rev Neurosci. 2009. PMID: 19826436 Review.
See all similar articles

Cited by

See all "Cited by" articles

Publication types

Substances

LinkOut - more resources