Five-year follow-up of fundus autofluorescence and retinal sensitivity in the fellow eye in exudative age-related macular degeneration in Japan

PLoS One. 2020 Mar 6;15(3):e0229694. doi: 10.1371/journal.pone.0229694. eCollection 2020.

Abstract

Purpose: To assess the 5-year change in abnormal fundus autofluorescence (FAF) patterns and retinal sensitivity in the fellow eye of Japanese patients with unilateral exudative age-related macular degeneration (AMD).

Methods: Patients with unilateral exudative AMD who developed abnormal FAF in the fellow eyes were enrolled. FAF imaging and microperimetry were performed at baseline and follow-ups. FAF findings were classified into 8 patterns based on the International Fundus Autofluorescence Classification Group to assess retinal sensitivity. Forty-five points covering the central 12 degrees on microperimetry were superimposed onto the FAF images. Each point was classified depending on the distance from the abnormal FAF. "Close" was defined as the portion within 1 degree from the border of any abnormal FAF, and "Distant" was defined as the portion over 1 degree from the border of abnormal FAF. To investigate the association between the retinal sensitivity and distance from the abnormal FAF, hierarchical linear mixed-effect models were used with the distance, time and time squared from baseline (months), and angle (degrees) as fixed effects. Differences among patients, eyes, and test point locations were considered successively nested random effects.

Results: We studied 66 fellow eyes with abnormal FAF. Twenty-seven eyes were followed-up during the 5 years. In the 13 of 27 eyes (48%), the abnormal FAF patterns had changed during the 5 years. We found retinal sensitivity was associated significantly with the distance from the abnormal FAF ("Distant": p<0.001, time2 from baseline: p<0.001, angle: p<0.001). The mean retinal sensitivity of the "Close" tended to deteriorate after the third year and eventually showed the similar sensitivity as the portion within the abnormal FAF.

Conclusion: FAF patterns can change about half during the 5 years and the retinal sensitivity near abnormal FAF tends to deteriorate after the third year.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Disease Progression
  • Female
  • Follow-Up Studies
  • Fundus Oculi
  • Humans
  • Japan
  • Linear Models
  • Macular Degeneration / diagnostic imaging*
  • Macular Degeneration / physiopathology*
  • Male
  • Middle Aged
  • Optical Imaging*
  • Retina / diagnostic imaging
  • Retina / physiopathology
  • Time Factors
  • Visual Field Tests

Grant support

Santen Pharmaceutical Co., Ltd. provided support in the form of honoraria for speaking and/or organizing at meetings (AS, MS, RM, TS, Yuji Oshima, TI, Yuichiro Ogura, FG, TY), but did not have any additional role in the study design, data analysis, decision to publish, or preparation of the manuscript. Santen Pharmaceutical Co., Ltd.provided support in the form of salaries for authors [MN, KM, NK, and EK], but did not have any additional role in the study design, data analysis, decision to publish, or preparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This work was also supported by JSPS KAKENHI Grant Number JP19K18893.