Renewing the Fight Against TB with an Old Vaccine

Thomas J Scriba; Valerie Mizrahi

doi:10.1016/j.cell.2020.02.024

Renewing the Fight Against TB with an Old Vaccine

Cell. 2020 Mar 5;180(5):829-831. doi: 10.1016/j.cell.2020.02.024.

Authors

Thomas J Scriba¹, Valerie Mizrahi²

Affiliations

¹ South African Tuberculosis Vaccine Initiative and Institute of Infectious Disease and Molecular Medicine, Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa.
² SAMRC/NHLS/UCT Molecular Mycobacteriology Research Unit and Institute of Infectious Disease and Molecular Medicine. Division of Medical Microbiology, Department of Pathology, University of Cape Town, Cape Town, South Africa; Wellcome Centre for Infectious Diseases Research in Africa, University of Cape Town, Cape Town, South Africa. Electronic address: valerie.mizrahi@uct.ac.za.

PMID: 32142676
DOI: 10.1016/j.cell.2020.02.024

Abstract

Prevention of pulmonary tuberculosis by vaccination has proven an elusive goal. In a recent study, Darrah et al. show that prevention of infection and disease can be achieved in non-human primates by intravenous administration of the century-old vaccine BCG. This finding heralds a step-change in the approach to TB vaccine development.

Publication types

Comment

MeSH terms

Administration, Intravenous
Animals
BCG Vaccine*
Macaca
Tuberculosis*
Vaccination

Substances

BCG Vaccine