Effect of Radiation on DCE-MRI Pharmacokinetic Parameters in a Rabbit Model of Compromised Maxillofacial Wound Healing: A Pilot Study

Stacey L Piotrowski; Lindsay Wilson; Kiersten L Maldonado; Ramesh Tailor; Lori R Hill; James A Bankson; Stephen Lai; F Kurtis Kasper; Simon Young

doi:10.1016/j.joms.2020.02.001

Effect of Radiation on DCE-MRI Pharmacokinetic Parameters in a Rabbit Model of Compromised Maxillofacial Wound Healing: A Pilot Study

J Oral Maxillofac Surg. 2020 Jun;78(6):1034.e1-1034.e10. doi: 10.1016/j.joms.2020.02.001. Epub 2020 Feb 11.

Authors

Stacey L Piotrowski¹, Lindsay Wilson², Kiersten L Maldonado³, Ramesh Tailor⁴, Lori R Hill⁵, James A Bankson⁶, Stephen Lai⁷, F Kurtis Kasper⁸, Simon Young⁹

Affiliations

¹ Anatomic Pathology Resident and PhD Student, Department of Comparative Pathobiology, Purdue University College of Veterinary Medicine, West Lafayette, IN; and Molecular Pathology Fellow, National Institutes of Health Comparative Biomedical Scientist Training Program, Bethesda, MD.
² Research Assistant III, Department of Oral and Maxillofacial Surgery, The University of Texas Health Science Center at Houston School of Dentistry, Houston, TX.
³ Imaging Research Technician, Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX.
⁴ Associate Professor, Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX.
⁵ Associate Professor, Department of Veterinary Medicine and Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX.
⁶ Professor, Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX.
⁷ Professor, Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX.
⁸ Associate Professor, Department of Orthodontics, The University of Texas Health Science Center at Houston School of Dentistry, Houston, TX.
⁹ Assistant Professor, Department of Oral and Maxillofacial Surgery, The University of Texas Health Science Center at Houston School of Dentistry, Houston, TX. Electronic address: simon.young@uth.tmc.edu.

PMID: 32147226
DOI: 10.1016/j.joms.2020.02.001

Abstract

Purpose: Osteoradionecrosis (ORN), a potentially debilitating complication of maxillofacial radiation, continues to present a challenging clinical scenario, with limited treatment options that often fail. Translational animal models that can accurately mimic the human characteristics of the condition are lacking. In the present pilot study, we aimed to characterize the effects of radiation on the dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) pharmacokinetic parameters in a rabbit model of compromised maxillofacial wound healing to determine its potential as a translational model of ORN.

Materials and methods: An experimental group underwent fractionated radiation of the mandible totaling 36 Gy. At 4 weeks after irradiation, the experimental and control groups (n = 8 rabbits each) underwent a surgical procedure to create a critical size defect in the mandibular bone. DCE-MRI scans were acquired 1 week after arrival (baseline; time point 1), 4 weeks after completion of irradiation in the experimental group (just before surgery, time point 2), and 4 weeks after surgery (time point 3).

Results: No differences in the analyzed DCE-MRI parameters were noted within the experimental or control group between the baseline values (time point 1) and those after irradiation (time point 2). The whole blood volume fraction (v_b) in the experimental group was increased compared with that in the control group after irradiation (time point 2; P < .05). After surgery (time point 3), both the forward flux rate of contrast from blood plasma and the extracellular extravascular space and the v_b were increased in the control group compared with the experimental group (P < .05).

Conclusions: The results of the present study suggest that DCE-MRI of a rabbit model of compromised maxillofacial wound healing could reflect the DCE-MRI characteristics of human patients with ORN and those at risk of developing the condition. Future studies will focus on further characterization of this rabbit model as a translational preclinical model of ORN.

MeSH terms

Animals
Contrast Media*
Humans
Magnetic Resonance Imaging*
Pilot Projects
Rabbits
Wound Healing

Substances

Contrast Media

Grants and funding

P30 CA016672/CA/NCI NIH HHS/United States