Burden of Pancreatic Cancer: From Epidemiology to Practice

Clin Gastroenterol Hepatol. 2021 May;19(5):876-884. doi: 10.1016/j.cgh.2020.02.054. Epub 2020 Mar 6.


Pancreatic cancer is the seventh leading cause of cancer-related deaths worldwide with 432,242 related deaths in 2018. Unlike other cancers, the incidence of pancreatic cancer continues to increase, with little improvement in survival rates. We review the epidemiologic features of pancreatic cancer, covering surveillance and early detection in high-risk persons. We summarize data on worldwide incidence and mortality and analyze the 1975-2016 data from 9 registries of the National Cancer Institute's Surveillance, Epidemiology, and End Results study, on the overall burden of pancreatic cancer as well as age-, sex-, and race-specific incidence, survival rates and trends. It is important to increase our knowledge of the worldwide and regional epidemiologic features of and risk factors for pancreatic cancer, to identify new approaches for prevention, surveillance, and treatment.

Keywords: PDAC; Pancreatic Adenocarcinoma; Prevalence; SEER Program.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Humans
  • Incidence
  • Pancreatic Neoplasms* / epidemiology
  • Registries
  • Risk Factors
  • Survival Rate
  • United States / epidemiology