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. 2020 Jan 1;2020:baaa012.
doi: 10.1093/database/baaa012.

CancerLivER: A Database of Liver Cancer Gene Expression Resources and Biomarkers

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Free PMC article

CancerLivER: A Database of Liver Cancer Gene Expression Resources and Biomarkers

Harpreet Kaur et al. Database (Oxford). .
Free PMC article

Abstract

Liver cancer is the fourth major lethal malignancy worldwide. To understand the development and progression of liver cancer, biomedical research generated a tremendous amount of transcriptomics and disease-specific biomarker data. However, dispersed information poses pragmatic hurdles to delineate the significant markers for the disease. Hence, a dedicated resource for liver cancer is required that integrates scattered multiple formatted datasets and information regarding disease-specific biomarkers. Liver Cancer Expression Resource (CancerLivER) is a database that maintains gene expression datasets of liver cancer along with the putative biomarkers defined for the same in the literature. It manages 115 datasets that include gene-expression profiles of 9611 samples. Each of incorporated datasets was manually curated to remove any artefact; subsequently, a standard and uniform pipeline according to the specific technique is employed for their processing. Additionally, it contains comprehensive information on 594 liver cancer biomarkers which include mainly 315 gene biomarkers or signatures and 178 protein- and 46 miRNA-based biomarkers. To explore the full potential of data on liver cancer, a web-based interactive platform was developed to perform search, browsing and analyses. Analysis tools were also integrated to explore and visualize the expression patterns of desired genes among different types of samples based on individual gene, GO ontology and pathways. Furthermore, a dataset matrix download facility was provided to facilitate the users for their extensive analysis to elucidate more robust disease-specific signatures. Eventually, CancerLivER is a comprehensive resource which is highly useful for the scientific community working in the field of liver cancer.Availability: CancerLivER can be accessed on the web at https://webs.iiitd.edu.in/raghava/cancerliver.

Keywords: Biomarkers; Datasets; Expression; Liver Cancer; Resource; transcriptomics.

Figures

Figure 1
Figure 1. Workflow to generate Expression Dataset matrices maintained in CancerLivER.
Figure 2
Figure 2. Architecture of CancerLivER.
Figure 3
Figure 3. Potential applications of CancerLivER.
Figure 4
Figure 4. The workflow shows the process of application of CancerLivER in the prioritisation of GPC3 as a diagnostic biomarker and as a drug target for HCC.

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