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Review
. 2020 Nov;33(6):788-805.
doi: 10.1111/pcmr.12874. Epub 2020 Mar 20.

An update on the implications of cyclin D1 in melanomas

Lucia González-Ruiz  1 , Miguel Ángel González-Moles  2   3 , Isabel González-Ruiz  2 , Isabel Ruiz-Ávila  3   4 , Ángela Ayén  5 , Pablo Ramos-García  2
Affiliations
Free article
Review

An update on the implications of cyclin D1 in melanomas

Lucia González-Ruiz et al. Pigment Cell Melanoma Res. 2020 Nov.
Free article

Abstract

Cyclin D1 is a protein encoded by the CCND1 gene, located on 11q13 chromosome, which is a key component of the physiological regulation of the cell cycle. CCND1/cyclin D1 is upregulated in several types of human tumors including melanoma and is currently classified as an oncogene that promotes uncontrolled cell proliferation. Despite the demonstrated importance of CCND1/cyclin D1 as a central oncogene in several types of human tumors, its knowledge in melanoma is still limited. This review examines data published on upregulation of the CCND1 gene and cyclin D1 protein in the melanoma setting, focusing on the pathways and molecular mechanisms involved in the activation of the gene and on the clinical and therapeutic implications.

Keywords: CCND1; cyclin D1; melanoma; skin carcinogenesis.

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