Introduction: Both beta-amyloid (Ab) deposition and decline in white matter integrity, are brain alterations observed in Alzheimer's disease (AD) and start to occur by the fourth and fifth decades. However, the association between both brain alterations in asymptomatic subjects is unclear.
Methods: Amyloid positron emission tomography (PET) and diffusion tensor imaging (DTI) were obtained in 282 cognitively normal subjects (age 30-89 years). We assessed the interaction of age by abnormal amyloid PET status (Florbetapir F-18 PET >1.2 standard uptake value ratio [SUVR]) on regional mean diffusivity (MD) and global white matter hyperintensity (WMH) volume, controlled for sex, education, and hypertension.
Results: Subjects with abnormal amyloid PET (n = 87) showed stronger age-related increase in global WMH and regional MD, particularly within the posterior parietal regions of the white matter.
Discussion: Sporadic Aβ deposition is associated with white matter alterations in AD predilection areas in an age-dependent manner in cognitively normal individuals.
Keywords: Alzheimer's disease; amyloid β; diffusion tensor imaging; life span; mean diffusivity; white matter; white matter hyperintensities.
© 2020 The Authors. Alzheimer's & Dementia published by Wiley Periodicals, Inc. on behalf of Alzheimer's Association.
Associations between white matter microstructure and amyloid burden in preclinical Alzheimer's disease: A multimodal imaging investigation.Neuroimage Clin. 2014 Feb 19;4:604-14. doi: 10.1016/j.nicl.2014.02.001. eCollection 2014. Neuroimage Clin. 2014. PMID: 24936411 Free PMC article.
Regional Amyloid-β Load and White Matter Abnormalities Contribute to Hypometabolism in Alzheimer's Dementia.Mol Neurobiol. 2019 Jul;56(7):4916-4924. doi: 10.1007/s12035-018-1405-1. Epub 2018 Nov 9. Mol Neurobiol. 2019. PMID: 30414086
The effect of white matter hyperintensities on statistical analysis of diffusion tensor imaging in cognitively healthy elderly and prodromal Alzheimer's disease.PLoS One. 2017 Sep 21;12(9):e0185239. doi: 10.1371/journal.pone.0185239. eCollection 2017. PLoS One. 2017. PMID: 28934374 Free PMC article.
Genetic influences on white matter and metabolism abnormal change in Alzheimer's disease: Meta-analysis for neuroimaging research on presenilin 1 mutation.Clin Neurol Neurosurg. 2019 Feb;177:47-53. doi: 10.1016/j.clineuro.2018.12.016. Epub 2018 Dec 26. Clin Neurol Neurosurg. 2019. PMID: 30599314 Review.
Spreading of amyloid, tau, and microvascular pathology in Alzheimer's disease: findings from neuropathological and neuroimaging studies.J Alzheimers Dis. 2014;42 Suppl 4:S421-9. doi: 10.3233/JAD-141461. J Alzheimers Dis. 2014. PMID: 25227313 Review.