Precancerous Gastric Lesions with Helicobacter pylori vacA +/ babA 2+/ oipA + Genotype Increase the Risk of Gastric Cancer

Theeraya Simawaranon Bartpho; Wareeporn Wattanawongdon; Taweesak Tongtawee; Chatchanok Paoin; Kokiet Kangwantas; Chavaboon Dechsukhum

doi:10.1155/2020/7243029

Precancerous Gastric Lesions with Helicobacter pylori vacA ⁺/ babA 2⁺/ oipA ⁺ Genotype Increase the Risk of Gastric Cancer

Biomed Res Int. 2020 Feb 18:2020:7243029. doi: 10.1155/2020/7243029. eCollection 2020.

Authors

Theeraya Simawaranon Bartpho¹, Wareeporn Wattanawongdon¹, Taweesak Tongtawee^{1

2}, Chatchanok Paoin³, Kokiet Kangwantas³, Chavaboon Dechsukhum⁴

Affiliations

¹ Translational Medicine Programs, Institute of Medicine, Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand.
² School of Surgery, Institute of Medicine, Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand.
³ School of Oncology, Institute of Medicine, Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand.
⁴ School of Pathology, Institute of Medicine, Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand.

Abstract

Objective: The clinical outcomes of gastric diseases such as chronic gastritis, peptic ulcer, and gastric cancer have been attributed to the interplay of virulence factors of Helicobacter pylori (H. pylori), host genetic susceptibility, and host immune responses. This study investigated the presence of cagA, vacA, iceA2, babA2, and oipA genes and their association with clinical outcomes.

Methods: Chronic gastritis, atrophic gastritis, and intestinal metaplasia specimens were obtained from patients who underwent endoscopy and surgical resection between January 2017 and December 2018; specimens from gastric cancer patients treated between January 2014 and December 2018 were also added. H. pylori), host genetic susceptibility, and host immune responses. This study investigated the presence of cagA, vacA, iceA2, babA2, and oipA genes and their association with clinical outcomes. H. pylori), host genetic susceptibility, and host immune responses. This study investigated the presence of.

Results: H. pylori), host genetic susceptibility, and host immune responses. This study investigated the presence of vacA, babA2, and oipA genes and their association with clinical outcomes. vacA, babA2, and oipA genes and their association with clinical outcomes. P=0.033, OR = 2.64; 95% CI = 1.44-4.82, P=0.033, OR = 2.64; 95% CI = 1.44-4.82, P=0.033, OR = 2.64; 95% CI = 1.44-4.82, H. pylori vacA ⁺/babA2, and oipA genes and their association with clinical outcomes. P=0.033, OR = 2.64; 95% CI = 1.44-4.82.

Conclusion: In this present study, we reported on the virulence genes of H. pylori infection to reveal their association with increased risk of chronic gastritis, precancerous gastric lesions, and gastric cancer. Precancerous gastric lesions with H. pylori vacA+/babA2+/oipA+ genotype increased the risk of gastric cancer.H. pylori), host genetic susceptibility, and host immune responses. This study investigated the presence of H. pylori vacA ⁺/babA2, and oipA genes and their association with clinical outcomes.

MeSH terms

Adhesins, Bacterial / genetics*
Bacterial Outer Membrane Proteins / genetics*
Bacterial Proteins / genetics*
Gastritis
Genotype*
Helicobacter Infections / genetics
Helicobacter pylori / genetics*
Stomach Neoplasms / genetics*
Stomach Neoplasms / microbiology
Virulence Factors / genetics

Substances

Adhesins, Bacterial
BabA protein, Helicobacter pylori
Bacterial Outer Membrane Proteins
Bacterial Proteins
IceA2 protein, Helicobacter pylori
OipA protein, Helicobacter pylori
VacA protein, Helicobacter pylori
Virulence Factors