Metabolic Syndrome and psoriatic arthritis: considerations for the clinician

Expert Rev Clin Immunol. 2020 Apr;16(4):409-420. doi: 10.1080/1744666X.2020.1740593. Epub 2020 Apr 1.


Introduction: Metabolic Syndrome (MetS) is strictly interconnected with systemic inflammation, and increased evidence has described a close link between this condition and Psoriatic Arthritis (PsA).Areas covered: This review summarizes main studies exploring clinical aspects and prevalence of MetS in PsA cohorts. Further, there is accumulating evidence showing shared inflammatory pathways between MetS, its components, and PsA.Expert opinion: The high prevalence of MetS in PsA highlights the need for screening, evaluation, and close monitoring of MetS and its components (namely, diabetes mellitus, obesity, hypertension, and dyslipidemia) in psoriatic patients.Further studies should focus on the pathogenetic link between MetS and PsA. More studies are required to identify appropriate algorithms for the assessment and management of MetS in PsA patients.

Keywords: Metabolic Syndrome; Psoriatic arthritis; adipokines; cardiovascular risk; obesity.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Arthritis, Psoriatic / epidemiology
  • Arthritis, Psoriatic / immunology*
  • Cardiovascular Diseases / epidemiology
  • Cardiovascular Diseases / immunology*
  • Dyslipidemias
  • Humans
  • Hypertension
  • Inflammation / immunology*
  • Metabolic Syndrome / epidemiology
  • Metabolic Syndrome / immunology*
  • Physicians*
  • Risk Factors