Regulation of Necroptosis by Phospholipids and Sphingolipids

Cells. 2020 Mar 5;9(3):627. doi: 10.3390/cells9030627.

Abstract

Several non-apoptotic regulated cell death pathways have been recently reported. Necroptosis, a form of necrotic-regulated cell death, is characterized by the involvement of receptor-interacting protein kinases and/or the pore-forming mixed lineage kinase domain-like protein. Recent evidence suggests a key role for lipidic molecules in the regulation of necroptosis. The purpose of this mini-review is to outline the regulation of necroptosis by sphingolipids and phospholipids.

Keywords: ceramide; fatty acids; lipids; mixed lineage kinase-domain like; necroptosis; phosphatidylinositols.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Ceramides / genetics
  • Ceramides / metabolism
  • Humans
  • Necroptosis / physiology*
  • Phospholipids / metabolism*
  • Protein Kinases / metabolism
  • Receptor-Interacting Protein Serine-Threonine Kinases / metabolism*
  • Sphingolipids / metabolism*

Substances

  • Ceramides
  • Phospholipids
  • Sphingolipids
  • Protein Kinases
  • Receptor-Interacting Protein Serine-Threonine Kinases